Dietary supplementation with CUR and CEL+CUR produced a significantly increased mean yellowness (b*) value in both, the skin of thigh muscle and footpad, of broilers (P< 0.05), in comparison with the rest of the groups that did not receive CUR as part of the diet, suggesting that there may be a greater absorption of CUR due to the improvement of its solubility, resulting in a better intestinal absorption, and therefore, a higher level of yellowness. and CEL showed a better-integrated approach for the management of poultry health problems that are related with the consumption of AFB1, since they have different mechanisms of action with different positive effects on the responses of broiler chickens. Keywords:aflatoxin B1, broiler chickens, cellulosic polymers, curcumin, overall performance == 1. Introduction == Poultry and mycotoxins have been closely linked for several Rabbit polyclonal to ATF2 decades, as they are one of the most sensitive animal species to the harmful effects of mycotoxins. In the poultry industry, the ingestion of aflatoxin B1 (AFB1) lead to the impairment of all the essential productive parameters [1,2] and decreased resistance to common infectious diseases due to Xanthiazone the depression of the humoral and cellular immune responses [3,4], resulting in substantial annual economic losses [5]. Furthermore, there is a public concern for the possible contamination with harmful residues into poultry products, such as meat and eggs, resulting in a potential hazard to human health, since the AFB1 residues may pass to these products at deficient levels [6]. Nowadays, there is no single method to counteract the harmful effects of AFB1, but different strategies and technologies have been implemented to address the difficulties that are related to AFB1 and its harmful effects [7,8]. Unquestionably, preventing the contamination of feed and grain with AFB1 is the best and first attempt; however, since prevention is not usually possible, chemical, physical, and biological methods to decontaminate or detoxify feed and grains have been gaining attention [9,10,11]. Among these, the use of adsorbents is the most widely studied method as an alternative to diminish the harmful effects of AFB1 in animals, due to its economic practicality and its aptness for nutritional insight [12]. Additionally, since AFB1 cause cell damage, free radical production, and lipid peroxidation, the use of antioxidants acting as superoxide anion scavengers could aid in the overall detoxification process in the liver, and hence may help in the alleviation of aflatoxicosis [13,14]. In this sense, for practicality and effectiveness reasons, the most recent dietary approach to prevent aflatoxicosis in poultry is the combined use of adsorbents and antioxidants [15]. Curcumin (CUR), a polyphenolic curcuminoid, is one of the active natural products that have been extensively analyzed. CUR has been shown to possess antioxidant, anti-inflammatory, antimutagenic, antimicrobial, and anticancer properties [16,17]. Some experts have exhibited that CUR can ameliorate AFB1 toxicity through the increased Xanthiazone activity of antioxidant enzymes, neutralizing the free radicals, and inhibiting AFB1 biotransformation into its 8,9-epoxide [18,19]. However, despite the exhibited positive effects of CUR, its Xanthiazone beneficial effects remain limited by its low solubility and poor bioavailability [20,21], which has motivated experts to use several strategies to increase both the solubility and bioavailability of CUR [22,23]. Previous research that was conducted in our laboratory has exhibited that cellulosic polymers have great potential to adsorb AFB1 in vitro [24], but in vivo studies are needed to confirm the effectiveness of these materials. Furthermore, we have focused on the improvement of the solubility and permeability of CUR through the formation of a stable dispersion with polyvinylpyrrolidone (PVP) [25], with the results suggesting that this increase in solubility of CUR could be involved in the improvement of its antimicrobial activity. Hence, the objective of this study was to evaluate the effectiveness of cellulosic polymers, a stable dispersion of CUR, and the combination of both in reducing the adverse effects of AFB1 on overall performance parameters, serum biochemical parameters, cellular and humoral immunity parameters, and pathological damages of the liver in broiler chickens. == 2. Results == The results of the overall performance.